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Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects.

Publication ,  Journal Article
O'Brien, KD; Brehm, BJ; Seeley, RJ; Bean, J; Wener, MH; Daniels, S; D'Alessio, DA
Published in: J Clin Endocrinol Metab
April 2005

Elevated levels of serum amyloid A (SAA) and C-reactive protein (CRP) have been associated with increased cardiovascular risk. Although levels of CRP decrease with weight loss, it is not known whether SAA decreases with weight loss or whether dietary macronutrient composition affects levels of either SAA or CRP. SAA and CRP levels were measured retrospectively on baseline and 3-month plasma samples from 41 obese (mean body mass index 33.63 +/- 1.86 kg/m2) women completing a randomized trial comparing a low-fat diet (n = 19) and a very low-carbohydrate diet (n = 22). For the 41 participants, there were significant decreases from baseline to 3 months in both LogSAA (P = 0.049) and LogCRP (P = 0.035). The very low-carbohydrate dieters had a significantly greater decrease in LogSAA (P = 0.04), but their weight loss also was significantly greater (-7.6 +/- 3.2 vs. -4.3 +/- 3.5 kg, P < 0.01). In this study, the decreases in inflammatory markers correlated significantly with weight loss (r = 0.44, P = 0.004 vs. LogSAA and r = 0.35, P = 0.03 vs. LogCRP). Also, change in LogSAA correlated with change in insulin resistance (r = 0.35, P = 0.03). Thus, in otherwise healthy, obese women, weight loss was associated with significant decreases in both SAA and CRP. These effects were proportional to the amount of weight lost but independent of dietary macronutrient composition.

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Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

April 2005

Volume

90

Issue

4

Start / End Page

2244 / 2249

Location

United States

Related Subject Headings

  • Weight Loss
  • Serum Amyloid A Protein
  • Obesity
  • Lipids
  • Insulin Resistance
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Dietary Fats
  • Dietary Carbohydrates
 

Citation

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O’Brien, K. D., Brehm, B. J., Seeley, R. J., Bean, J., Wener, M. H., Daniels, S., & D’Alessio, D. A. (2005). Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects. J Clin Endocrinol Metab, 90(4), 2244–2249. https://doi.org/10.1210/jc.2004-1011
O’Brien, Kevin D., Bonnie J. Brehm, Randy J. Seeley, Judy Bean, Mark H. Wener, Stephen Daniels, and David A. D’Alessio. “Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects.J Clin Endocrinol Metab 90, no. 4 (April 2005): 2244–49. https://doi.org/10.1210/jc.2004-1011.
O’Brien KD, Brehm BJ, Seeley RJ, Bean J, Wener MH, Daniels S, et al. Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects. J Clin Endocrinol Metab. 2005 Apr;90(4):2244–9.
O’Brien, Kevin D., et al. “Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects.J Clin Endocrinol Metab, vol. 90, no. 4, Apr. 2005, pp. 2244–49. Pubmed, doi:10.1210/jc.2004-1011.
O’Brien KD, Brehm BJ, Seeley RJ, Bean J, Wener MH, Daniels S, D’Alessio DA. Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects. J Clin Endocrinol Metab. 2005 Apr;90(4):2244–2249.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

April 2005

Volume

90

Issue

4

Start / End Page

2244 / 2249

Location

United States

Related Subject Headings

  • Weight Loss
  • Serum Amyloid A Protein
  • Obesity
  • Lipids
  • Insulin Resistance
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Dietary Fats
  • Dietary Carbohydrates