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Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36.

Publication ,  Journal Article
Pfluger, PT; Kampe, J; Castaneda, TR; Vahl, T; D'Alessio, DA; Kruthaupt, T; Benoit, SC; Cuntz, U; Rochlitz, HJ; Moehlig, M; Pfeiffer, AFH ...
Published in: J Clin Endocrinol Metab
February 2007

BACKGROUND: Recent findings suggest that low plasma peptide YY (PYY) levels may contribute to diet-induced human obesity and justify PYY replacement therapy. Although the pharmacological value of PYY is controversial, further study of the secretion of the precursor PYY(1-36) and the pharmacologically active PYY(3-36) is indicated to determine the potential role in energy balance regulation. AIM: Our objective was to determine the effects of acute and chronic changes in human body weight on circulating levels of the putative satiety hormone peptide YY. DESIGN: Total plasma PYY levels (PYY(1-36) + PYY(3-36)) were measured in 66 lean, 18 anorectic, 63 obese, and 16 morbidly obese humans. In addition, total PYY was measured in 17 of the obese patients after weight loss and in the 18 anorectic patients after weight gain. Fasting PYY(3-36) levels were measured in 17 lean and 15 obese individuals. RESULTS: Fasting total plasma PYY levels were highest in patients with anorexia nervosa (80.9 +/- 12.9 pg/ml, P < 0.05) compared with lean (52.4 +/- 4.6 pg/ml), obese (43.9 +/- 3.8 pg/ml), or morbidly obese (45.6 +/- 11.2 pg/ml) subjects. In obese patients, weight loss of 5.4% was associated with a 30% decrease in fasting total PYY plasma levels. In anorectic patients, weight gain had no effect on fasting PYY. PYY(3-36) levels did not differ between lean (96.2 +/- 8.6 pg/ml) and obese (91.5 +/- 6.9 pg/ml) subjects. CONCLUSION: Our findings do not support a role for abnormal circulating PYY in human obesity. We conclude that circulating PYY levels in humans are significantly elevated in anorexia nervosa and, given the controversially discussed anorectic effect of PYY, could theoretically contribute to that syndrome.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

February 2007

Volume

92

Issue

2

Start / End Page

583 / 588

Location

United States

Related Subject Headings

  • Weight Loss
  • Weight Gain
  • Satiety Response
  • Receptors, Leptin
  • Receptors, Cell Surface
  • Peptide YY
  • Peptide Fragments
  • Obesity, Morbid
  • Leptin
  • Humans
 

Citation

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MLA
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Pfluger, P. T., Kampe, J., Castaneda, T. R., Vahl, T., D’Alessio, D. A., Kruthaupt, T., … Tschöp, M. H. (2007). Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J Clin Endocrinol Metab, 92(2), 583–588. https://doi.org/10.1210/jc.2006-1425
Pfluger, P. T., J. Kampe, T. R. Castaneda, T. Vahl, D. A. D’Alessio, T. Kruthaupt, S. C. Benoit, et al. “Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36.J Clin Endocrinol Metab 92, no. 2 (February 2007): 583–88. https://doi.org/10.1210/jc.2006-1425.
Pfluger PT, Kampe J, Castaneda TR, Vahl T, D’Alessio DA, Kruthaupt T, et al. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J Clin Endocrinol Metab. 2007 Feb;92(2):583–8.
Pfluger, P. T., et al. “Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36.J Clin Endocrinol Metab, vol. 92, no. 2, Feb. 2007, pp. 583–88. Pubmed, doi:10.1210/jc.2006-1425.
Pfluger PT, Kampe J, Castaneda TR, Vahl T, D’Alessio DA, Kruthaupt T, Benoit SC, Cuntz U, Rochlitz HJ, Moehlig M, Pfeiffer AFH, Koebnick C, Weickert MO, Otto B, Spranger J, Tschöp MH. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J Clin Endocrinol Metab. 2007 Feb;92(2):583–588.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

February 2007

Volume

92

Issue

2

Start / End Page

583 / 588

Location

United States

Related Subject Headings

  • Weight Loss
  • Weight Gain
  • Satiety Response
  • Receptors, Leptin
  • Receptors, Cell Surface
  • Peptide YY
  • Peptide Fragments
  • Obesity, Morbid
  • Leptin
  • Humans