New ways in which GLP-1 can regulate glucose homeostasis.


Journal Article

Glucagon-like peptide-1 (GLP-1) has a diverse set of peripheral actions which all serve to promote enhanced glucose tolerance, and for this reason it has become the basis for new treatments for type 2 diabetes. In this issue of the JCI, Knauf et al. provide clear evidence that GLP-1 signaling in the CNS is also linked to the control of peripheral glucose homeostasis by inhibiting non-insulin-mediated glucose uptake by muscle and increasing insulin secretion from the pancreas. The authors' work points to an important need to integrate diverse GLP-1 signaling actions and peripheral GLP-1 function in order to better understand both normal and abnormal glucose homeostasis.

Full Text

Duke Authors

Cited Authors

  • D'Alessio, DA; Sandoval, DA; Seeley, RJ

Published Date

  • December 2005

Published In

Volume / Issue

  • 115 / 12

Start / End Page

  • 3406 - 3408

PubMed ID

  • 16322789

Pubmed Central ID

  • 16322789

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI27207


  • eng

Conference Location

  • United States