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Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.

Publication ,  Journal Article
Proulx, K; Cota, D; Castañeda, TR; Tschöp, MH; D'Alessio, DA; Tso, P; Woods, SC; Seeley, RJ
Published in: Am J Physiol Regul Integr Comp Physiol
September 2005

Oleoylethanolamide (OEA), a lipid synthesized in the intestine, reduces food intake and stimulates lipolysis through peroxisome proliferator-activated receptor-alpha. OEA also activates transient receptor potential vanilloid type 1 (TRPV1) in vitro. Because the anorexigenic effect of OEA is associated with delayed feeding onset and reduced locomotion, we examined whether intraperitoneal administration of OEA results in nonspecific behavioral effects that contribute to the anorexia in rats. Moreover, we determined whether circulating levels of other gut hormones are modulated by OEA and whether CCK is involved in OEA-induced anorexia. Our results indicate that OEA reduces food intake without causing a conditioned taste aversion or reducing sodium appetite. It also failed to induce a conditioned place aversion. However, OEA induced changes in posture and reduced spontaneous activity in the open field. This likely underlies the reduced heat expenditure and sodium consumption observed after OEA injection, which disappeared within 1 h. The effects of OEA on motor activity were similar to those of the TRPV1 agonist capsaicin and were also observed with the peroxisome proliferator-activated receptor-alpha agonist Wy-14643. Plasma levels of ghrelin, peptide YY, glucagon-like peptide 1, and apolipoprotein A-IV were not changed by OEA. Finally, antagonism of CCK-1 receptors did not affect OEA-induced anorexia. These results suggest that OEA suppresses feeding without causing visceral illness and that neither ghrelin, peptide YY, glucagon-like peptide 1, apolipoprotein A-IV, nor CCK plays a critical role in this effect. Despite that OEA-induced anorexia is unlikely to be due to impaired motor activity, our data raise a cautionary note in how specific behavioral and metabolic effects of OEA should be interpreted.

Duke Scholars

Published In

Am J Physiol Regul Integr Comp Physiol

DOI

ISSN

0363-6119

Publication Date

September 2005

Volume

289

Issue

3

Start / End Page

R729 / R737

Location

United States

Related Subject Headings

  • Taste
  • Space Perception
  • Sodium
  • Rats, Long-Evans
  • Rats
  • Pyrimidines
  • Proglumide
  • Physiology
  • Motor Activity
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Proulx, K., Cota, D., Castañeda, T. R., Tschöp, M. H., D’Alessio, D. A., Tso, P., … Seeley, R. J. (2005). Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol, 289(3), R729–R737. https://doi.org/10.1152/ajpregu.00029.2005
Proulx, Karine, Daniela Cota, Tamara R. Castañeda, Matthias H. Tschöp, David A. D’Alessio, Patrick Tso, Stephen C. Woods, and Randy J. Seeley. “Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.Am J Physiol Regul Integr Comp Physiol 289, no. 3 (September 2005): R729–37. https://doi.org/10.1152/ajpregu.00029.2005.
Proulx K, Cota D, Castañeda TR, Tschöp MH, D’Alessio DA, Tso P, et al. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R729–37.
Proulx, Karine, et al. “Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.Am J Physiol Regul Integr Comp Physiol, vol. 289, no. 3, Sept. 2005, pp. R729–37. Pubmed, doi:10.1152/ajpregu.00029.2005.
Proulx K, Cota D, Castañeda TR, Tschöp MH, D’Alessio DA, Tso P, Woods SC, Seeley RJ. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R729–R737.

Published In

Am J Physiol Regul Integr Comp Physiol

DOI

ISSN

0363-6119

Publication Date

September 2005

Volume

289

Issue

3

Start / End Page

R729 / R737

Location

United States

Related Subject Headings

  • Taste
  • Space Perception
  • Sodium
  • Rats, Long-Evans
  • Rats
  • Pyrimidines
  • Proglumide
  • Physiology
  • Motor Activity
  • Male