CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors.

Journal Article (Journal Article)

Responses to stressors serve to adjust physiology and behavior to increase short-term survival at the potential expense of increasing susceptibility to disease over the long term. We show that glucagon-like peptide-1 (7-36) amide (GLP-1) increases levels of the stress-activated hormones ACTH and corticosterone when administered directly into the rat brain and increases levels of anxiety as measured by the elevated plus maze. The endocrine response is preferentially activated by GLP-1 administration in the paraventricular nucleus of the hypothalamus, whereas the anxiety response is preferentially activated by administration in the central nucleus of the amygdala. Furthermore, GLP-1 antagonists block increases in stress hormones associated with the toxin LiCl and both the endocrine and anxiety responses to vertical heights. Although diverse neural circuits must necessarily process disparate stressors, the current data implicate a role for the GLP-1 system as a critical mediator of multiple stress responses.

Full Text

Duke Authors

Cited Authors

  • Kinzig, KP; D'Alessio, DA; Herman, JP; Sakai, RR; Vahl, TP; Figueiredo, HF; Murphy, EK; Seeley, RJ

Published Date

  • July 16, 2003

Published In

Volume / Issue

  • 23 / 15

Start / End Page

  • 6163 - 6170

PubMed ID

  • 12867498

Pubmed Central ID

  • PMC6740553

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.23-15-06163.2003


  • eng

Conference Location

  • United States