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Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats.

Publication ,  Journal Article
Strader, AD; Vahl, TP; Jandacek, RJ; Woods, SC; D'Alessio, DA; Seeley, RJ
Published in: Am J Physiol Endocrinol Metab
February 2005

Bariatric surgeries, such as gastric bypass, result in dramatic and sustained weight loss that is usually attributed to a combination of gastric volume restriction and intestinal malabsorption. However, studies parceling out the contribution of enhanced intestinal stimulation in the absence of these two mechanisms have received little attention. Previous studies have demonstrated that patients who received intestinal bypass or Roux-en-Y surgery have increased release of gastrointestinal hormones. One possible mechanism for this increase is the rapid transit of nutrients into the intestine after eating. To determine whether there is increased secretion of anorectic peptides produced in the distal small intestine when this portion of the gut is given greater exposure to nutrients, we preformed ileal transpositions (IT) in rats. In this procedure, an isolated segment of ileum is transposed to the jejunum, resulting in an intestinal tract of normal length but an alteration in the normal distribution of endocrine cells along the gut. Rats with IT lost more weight (P < 0.05) and consumed less food (P < 0.05) than control rats with intestinal transections and reanastomosis without transposition. Weight loss in the IT rats was not due to malabsorption of nutrients. However, transposition of distal gut to a proximal location caused increased synthesis and release of the anorectic ileal hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY; P < 0.01). The association of weight loss with increased release of GLP-1 and PYY suggests that procedures that promote gastrointestinal endocrine function can reduce energy intake. These findings support the importance of evaluating the contribution of gastrointestinal hormones to the weight loss seen with bariatric surgery.

Duke Scholars

Published In

Am J Physiol Endocrinol Metab

DOI

ISSN

0193-1849

Publication Date

February 2005

Volume

288

Issue

2

Start / End Page

E447 / E453

Location

United States

Related Subject Headings

  • Weight Loss
  • Rats, Long-Evans
  • Rats
  • Protein Precursors
  • Peptide YY
  • Peptide Fragments
  • Male
  • Jejunum
  • Ilium
  • Glucagon-Like Peptide 1
 

Citation

APA
Chicago
ICMJE
MLA
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Strader, A. D., Vahl, T. P., Jandacek, R. J., Woods, S. C., D’Alessio, D. A., & Seeley, R. J. (2005). Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab, 288(2), E447–E453. https://doi.org/10.1152/ajpendo.00153.2004
Strader, April D., Torsten P. Vahl, Ronald J. Jandacek, Stephen C. Woods, David A. D’Alessio, and Randy J. Seeley. “Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats.Am J Physiol Endocrinol Metab 288, no. 2 (February 2005): E447–53. https://doi.org/10.1152/ajpendo.00153.2004.
Strader AD, Vahl TP, Jandacek RJ, Woods SC, D’Alessio DA, Seeley RJ. Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E447–53.
Strader, April D., et al. “Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats.Am J Physiol Endocrinol Metab, vol. 288, no. 2, Feb. 2005, pp. E447–53. Pubmed, doi:10.1152/ajpendo.00153.2004.
Strader AD, Vahl TP, Jandacek RJ, Woods SC, D’Alessio DA, Seeley RJ. Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E447–E453.

Published In

Am J Physiol Endocrinol Metab

DOI

ISSN

0193-1849

Publication Date

February 2005

Volume

288

Issue

2

Start / End Page

E447 / E453

Location

United States

Related Subject Headings

  • Weight Loss
  • Rats, Long-Evans
  • Rats
  • Protein Precursors
  • Peptide YY
  • Peptide Fragments
  • Male
  • Jejunum
  • Ilium
  • Glucagon-Like Peptide 1