Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro.

Published

Journal Article

To determine whether chronic overproduction of islet amyloid polypeptide alters beta-cell function, we studied a line of transgenic mice which overexpress islet amyloid polypeptide in their beta-cells. At 3 months of age, these transgenic mice had greater pancreatic content of both islet amyloid polypeptide and insulin. Further, basal and glucose-stimulated secretion of both islet amyloid polypeptide and insulin were also elevated in the perfused pancreas of the transgenic animals. These findings demonstrate that chronic overproduction and secretion of islet amyloid polypeptide are associated with increased insulin storage and enhanced secretion of insulin in vitro. This increase in insulin storage and secretion may be due to a direct effect of islet amyloid polypeptide on the beta-cell or a beta-cell adaptation to islet amyloid polypeptide-induced insulin resistance.

Full Text

Duke Authors

Cited Authors

  • Verchere, CB; D'Alessio, DA; Palmiter, RD; Kahn, SE

Published Date

  • July 1994

Published In

Volume / Issue

  • 37 / 7

Start / End Page

  • 725 - 728

PubMed ID

  • 7958546

Pubmed Central ID

  • 7958546

Electronic International Standard Serial Number (EISSN)

  • 1432-0428

International Standard Serial Number (ISSN)

  • 0012-186X

Digital Object Identifier (DOI)

  • 10.1007/bf00417699

Language

  • eng