Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway.

Journal Article (Journal Article)

To determine the potential for differential release of islet amyloid polypeptide and insulin, we performed studies in rat islet monolayer cultures under conditions known to impair regulated beta-cell secretion. In inhibiting concentrations of epinephrine or the absence of calcium, islet amyloid polypeptide was secreted through a constitutive pathway while insulin was not. These findings suggest a mechanism for persistent islet amyloid polypeptide secretion and amyloid accumulation when regulated insulin release is impaired as in Type 2 (non-insulin-dependent) diabetes mellitus and insulinomas.

Full Text

Duke Authors

Cited Authors

  • Kahn, SE; Verchere, CB; D'Alessio, DA; Cook, DL; Fujimoto, WY

Published Date

  • June 1993

Published In

Volume / Issue

  • 36 / 6

Start / End Page

  • 570 - 573

PubMed ID

  • 8335181

International Standard Serial Number (ISSN)

  • 0012-186X

Digital Object Identifier (DOI)

  • 10.1007/BF02743276


  • eng

Conference Location

  • Germany