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Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell.

Publication ,  Journal Article
Kahn, SE; Fujimoto, WY; D'Alessio, DA; Ensinck, JW; Porte, D
Published in: Horm Metab Res
December 1991

Islet amyloid polypeptide (IAPP) has been shown to be actively secreted by the pancreatic B-cell along with insulin. To determine whether the modulation of B-cell IAPP secretion is similar to that of insulin, we assessed IAPP release in response to glucose at 4 different concentrations (1.67, 5.5, 8.8 and 16.7 mM) and to non-glucose secretagogues at different glucose concentrations in a neonatal rat islet monolayer culture preparation. Glucose alone stimulated IAPP and insulin secretion in a dose dependent fashion with maximal release for both peptides occurring at 8.8 mM. B-cell secretion of IAPP in response to arginine, isobutylmethylxanthine or both together was potentiated by increasing glucose concentrations from 1.67 to 16.7 mM. This same pattern of glucose potentiation was observed for insulin secretion. The data indicate that the pattern of peptide responses of cultured neonatal B-cells to glucose is similar for both IAPP and insulin release. Furthermore, the data suggest that glucose is capable of potentiating B-cell secretion of both IAPP and insulin.

Duke Scholars

Published In

Horm Metab Res

DOI

ISSN

0018-5043

Publication Date

December 1991

Volume

23

Issue

12

Start / End Page

577 / 580

Location

Germany

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Islets of Langerhans
  • Islet Amyloid Polypeptide
  • Insulin Secretion
  • Insulin
  • Glucose
  • Endocrinology & Metabolism
  • Drug Synergism
  • Cells, Cultured
 

Citation

APA
Chicago
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MLA
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Kahn, S. E., Fujimoto, W. Y., D’Alessio, D. A., Ensinck, J. W., & Porte, D. (1991). Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. Horm Metab Res, 23(12), 577–580. https://doi.org/10.1055/s-2007-1003759
Kahn, S. E., W. Y. Fujimoto, D. A. D’Alessio, J. W. Ensinck, and D. Porte. “Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell.Horm Metab Res 23, no. 12 (December 1991): 577–80. https://doi.org/10.1055/s-2007-1003759.
Kahn SE, Fujimoto WY, D’Alessio DA, Ensinck JW, Porte D. Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. Horm Metab Res. 1991 Dec;23(12):577–80.
Kahn, S. E., et al. “Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell.Horm Metab Res, vol. 23, no. 12, Dec. 1991, pp. 577–80. Pubmed, doi:10.1055/s-2007-1003759.
Kahn SE, Fujimoto WY, D’Alessio DA, Ensinck JW, Porte D. Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. Horm Metab Res. 1991 Dec;23(12):577–580.
Journal cover image

Published In

Horm Metab Res

DOI

ISSN

0018-5043

Publication Date

December 1991

Volume

23

Issue

12

Start / End Page

577 / 580

Location

Germany

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Islets of Langerhans
  • Islet Amyloid Polypeptide
  • Insulin Secretion
  • Insulin
  • Glucose
  • Endocrinology & Metabolism
  • Drug Synergism
  • Cells, Cultured