Developing therapies for heart failure with preserved ejection fraction: current state and future directions.

Journal Article (Journal Article;Review)

The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is projected to worsen. To date, there are no approved therapies available for reducing mortality or hospitalizations for these patients. The pathophysiology of HFpEF is complex and includes alterations in cardiac structure and function, systemic and pulmonary vascular abnormalities, end-organ involvement, and comorbidities. There remain major gaps in our understanding of HFpEF pathophysiology. To facilitate a discussion of how to proceed effectively in future with development of therapies for HFpEF, a meeting was facilitated by the Food and Drug Administration and included representatives from academia, industry, and regulatory agencies. This document summarizes the proceedings from this meeting.

Full Text

Duke Authors

Cited Authors

  • Butler, J; Fonarow, GC; Zile, MR; Lam, CS; Roessig, L; Schelbert, EB; Shah, SJ; Ahmed, A; Bonow, RO; Cleland, JGF; Cody, RJ; Chioncel, O; Collins, SP; Dunnmon, P; Filippatos, G; Lefkowitz, MP; Marti, CN; McMurray, JJ; Misselwitz, F; Nodari, S; O'Connor, C; Pfeffer, MA; Pieske, B; Pitt, B; Rosano, G; Sabbah, HN; Senni, M; Solomon, SD; Stockbridge, N; Teerlink, JR; Georgiopoulou, VV; Gheorghiade, M

Published Date

  • April 2014

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • 97 - 112

PubMed ID

  • 24720916

Pubmed Central ID

  • PMC4028447

Electronic International Standard Serial Number (EISSN)

  • 2213-1787

Digital Object Identifier (DOI)

  • 10.1016/j.jchf.2013.10.006


  • eng

Conference Location

  • United States