Impact of perioperative blood pressure variability on health resource utilization after cardiac surgery: an analysis of the ECLIPSE trials.

Journal Article (Journal Article)

OBJECTIVE: To examine the impact of blood pressure control on hospital health resource utilization using data from the ECLIPSE trials. DESIGN: Post-hoc analysis of data from 3 prospective, open-label, randomized clinical trials (ECLIPSE trials). SETTING: Sixty-one medical centers in the United States. PARTICIPANTS: Patients 18 years or older undergoing cardiac surgery. INTERVENTIONS: Clevidipine was compared with nitroglycerin, sodium nitroprusside, and nicardipine. MEASUREMENTS AND MAIN RESULTS: The ECLIPSE trials included 3 individual randomized open-label studies comparing clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine. Blood pressure control was assessed as the integral of the cumulative area under the curve (AUC) outside specified systolic blood pressure ranges, such that lower AUC represents less variability. This analysis examined surgery duration, time to extubation, as well as intensive care unit (ICU) and hospital length of stay (LOS) in patients with AUC≤10 mmHg×min/h compared to patients with AUC>10 mmHg×min/h. One thousand four hundred ten patients were included for analysis; 736 patients (52%) had an AUC≤10 mmHg×min/h, and 674 (48%) had an AUC>10 mmHg×min/h. The duration of surgery and ICU LOS were similar between groups. Time to extubation and postoperative LOS were both significantly shorter (p = 0.05 and p<0.0001, respectively) in patients with AUC≤10. Multivariate analysis demonstrates AUC≤10 was significantly and independently associated with decreased time to extubation (hazard ratio 1.132, p = 0.0261) and postoperative LOS (hazard ratio 1.221, p = 0.0006). CONCLUSIONS: Based on data derived from the ECLIPSE studies, increased perioperative BP variability is associated with delayed time to extubation and increased postoperative LOS.

Full Text

Duke Authors

Cited Authors

  • Aronson, S; Levy, JH; Lumb, PD; Fontes, M; Wang, Y; Crothers, TA; Sulham, KA; Navetta, MS

Published Date

  • June 2014

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 579 - 585

PubMed ID

  • 24726635

Pubmed Central ID

  • 24726635

Electronic International Standard Serial Number (EISSN)

  • 1532-8422

Digital Object Identifier (DOI)

  • 10.1053/j.jvca.2014.01.004


  • eng

Conference Location

  • United States