Regulatory T cells are redirected to kill glioblastoma by an EGFRviii-targeted bispecific antibody


Journal Article

Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway. © 2013 Landes Bioscience.

Full Text

Duke Authors

Cited Authors

  • Choi, BD; Gedeon, PC; Sanchez-Perez, L; Bigner, DD; Sampson, JH

Published Date

  • December 1, 2013

Published In

Volume / Issue

  • 2 / 12

Start / End Page

  • 1 - 2

Electronic International Standard Serial Number (EISSN)

  • 2162-402X

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.4161/onci.26757

Citation Source

  • Scopus