Pharmacokinetics and safety of recently approved drugs used to treat methicillin-resistant Staphylococcus aureus infections in infants, children and adults.


Journal Article (Review)

Methicillin-resistant Staphylococcus aureus (MRSA) remains a significant cause of morbidity in hospitalized infants. Over the past 15 years, several drugs have been approved for the treatment of S. aureus infections in adults (linezolid, quinupristin/dalfopristin, daptomycin, telavancin, tigecycline and ceftaroline). The use of the majority of these drugs has extended into the treatment of MRSA infections in infants, frequently with minimal safety or dosing information. Only linezolid is approved for use in infants, and pharmacokinetic data in infants are limited to linezolid and daptomycin. Pediatric trials are underway for ceftaroline, telavancin, and daptomycin; however, none of these studies includes infants. Here, we review current pharmacokinetic, safety and efficacy data of these drugs with a specific focus in infants.

Full Text

Duke Authors

Cited Authors

  • Gostelow, M; Gonzalez, D; Smith, PB; Cohen-Wolkowiez, M

Published Date

  • May 2014

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 327 - 340

PubMed ID

  • 24716805

Pubmed Central ID

  • 24716805

Electronic International Standard Serial Number (EISSN)

  • 1751-2441

Digital Object Identifier (DOI)

  • 10.1586/17512433.2014.909281


  • eng

Conference Location

  • England