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Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy.

Publication ,  Journal Article
Lee, CK; Margossian, R; Sleeper, LA; Canter, CE; Chen, S; Tani, LY; Shirali, G; Szwast, A; Tierney, ESS; Campbell, MJ; Golding, F; Wang, Y ...
Published in: Pediatr Cardiol
April 2014

M-mode and 2-dimensional (2D) echocardiographic imaging are routinely used to quantify left-ventricular (LV) size and function in pediatric patients with dilated cardiomyopathy (DCM). The reproducibility of and correlation between these techniques are unknown. This analysis sought to compare interreader, intrareader, and interacquisition reproducibility of M-mode versus 2D measurements in pediatric DCM patients. The Ventricular Volume Variability study of the Pediatric Heart Network is a multicenter, prospective, observational study assessing the course of chronic DCM in children. Two sonographers performed baseline image acquisitions locally, and two readers performed measurements at the echocardiographic core laboratory. One reader repeated measurements 1 month later. These data were used to assess reproducibility and agreement between M-mode and 2D measurements. One hundred sixty-nine subjects were enrolled. M-mode had similar or greater reproducibility in both intrareader and interreader settings for LV dimensions, shortening fraction (SF), and most wall thicknesses. In contrast, 2D reproducibility was similar or better for nearly all variables in the interacquisition setting but not for SF. Interacquisition variability was approximately twice the intrareader variability. LV dimensions by either modality consistently had high reproducibility and had the highest agreement between modalities. In pediatric DCM patients, variability of linear echocardiographic assessment could be minimized by relying on a single reader and using a consistent method (M-mode or 2D) for serial measurements, preferably M-mode when SF is the primary variable of interest. Except for LV dimensions, M-mode and 2D values should not be used interchangeably due to poor agreement.

Duke Scholars

Published In

Pediatr Cardiol

DOI

EISSN

1432-1971

Publication Date

April 2014

Volume

35

Issue

4

Start / End Page

658 / 667

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Function, Left
  • Reproducibility of Results
  • ROC Curve
  • Male
  • Infant
  • Humans
  • Heart Ventricles
  • Female
  • Echocardiography
 

Citation

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Lee, C. K., Margossian, R., Sleeper, L. A., Canter, C. E., Chen, S., Tani, L. Y., … Pediatric Heart Network Investigators, . (2014). Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy. Pediatr Cardiol, 35(4), 658–667. https://doi.org/10.1007/s00246-013-0835-9
Lee, Caroline K., Renee Margossian, Lynn A. Sleeper, Charles E. Canter, Shan Chen, Lloyd Y. Tani, Girish Shirali, et al. “Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy.Pediatr Cardiol 35, no. 4 (April 2014): 658–67. https://doi.org/10.1007/s00246-013-0835-9.
Lee CK, Margossian R, Sleeper LA, Canter CE, Chen S, Tani LY, et al. Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy. Pediatr Cardiol. 2014 Apr;35(4):658–67.
Lee, Caroline K., et al. “Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy.Pediatr Cardiol, vol. 35, no. 4, Apr. 2014, pp. 658–67. Pubmed, doi:10.1007/s00246-013-0835-9.
Lee CK, Margossian R, Sleeper LA, Canter CE, Chen S, Tani LY, Shirali G, Szwast A, Tierney ESS, Campbell MJ, Golding F, Wang Y, Altmann K, Colan SD, Pediatric Heart Network Investigators. Variability of M-mode versus two-dimensional echocardiography measurements in children with dilated cardiomyopathy. Pediatr Cardiol. 2014 Apr;35(4):658–667.
Journal cover image

Published In

Pediatr Cardiol

DOI

EISSN

1432-1971

Publication Date

April 2014

Volume

35

Issue

4

Start / End Page

658 / 667

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Function, Left
  • Reproducibility of Results
  • ROC Curve
  • Male
  • Infant
  • Humans
  • Heart Ventricles
  • Female
  • Echocardiography