More serious infectious morbidity and mortality associated with simultaneous candidemia and coagulase-negative staphylococcal bacteremia in neonates and in vitro adherence studies between Candida albicans and Staphylococcus epidermidis.

Published

Journal Article

BACKGROUND: Candida species and coagulase-negative staphylococci (CoNS) are common etiologies of hospital acquired bloodstream infection in the neonatal intensive care unit (NICU). Sepsis with either organism may result in serious infectious sequelae and along with other staphylococci are the most common causes of abscess formation in preterm infants. This increased incidence of abscess formation may be in part due to adherence factors of both pathogens. METHODS: All cases of concurrent positive blood cultures for both Candida species and CoNS were identified from the microbiology database in NICU patients from January 1998 to December 2000 and analyzed for risk factors and outcomes. In vitro co-aggregation studies between Candida albicans and Staphylococcus epidermidis were also performed. RESULTS: Six premature infants were identified as having concurrent Candida and CoNS bloodstream infections during this time period. Four of the six patients developed end-organ dissemination with abscess or infected thrombus formation. Three of the six patients expired during or after their infection. In vitro, co-aggregation studies did not demonstrate reproducible direct adherence between C. albicans and S. epidermidis. CONCLUSIONS: Simultaneous bloodstream infection with Candida and CoNS, compared to either one alone, is more likely to predispose to abscess formation, septic thrombophlebitis and mortality. Further studies are needed to examine the pathogenesis of these complex infections.

Full Text

Duke Authors

Cited Authors

  • Kaufman, DA; Brown, AT; Eisenhuth, KK; Yue, J; Grossman, LB; Hazen, KC

Published Date

  • March 2014

Published In

Volume / Issue

  • 90 Suppl 1 /

Start / End Page

  • S66 - S70

PubMed ID

  • 24709464

Pubmed Central ID

  • 24709464

Electronic International Standard Serial Number (EISSN)

  • 1872-6232

International Standard Serial Number (ISSN)

  • 0378-3782

Digital Object Identifier (DOI)

  • 10.1016/s0378-3782(14)70021-0

Language

  • eng