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Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI.

Publication ,  Journal Article
Bashir, MR; Breault, SR; Braun, R; Do, RK; Nelson, RC; Reeder, SB
Published in: Acad Radiol
June 2014

RATIONALE AND OBJECTIVES: To evaluate clinical and imaging features associated with adequacy of the hepatocyte phase (HP) in gadoxetate disodium-enhanced liver magnetic resonance imaging (MRI) in patients without chronic liver disease (CLD). MATERIALS AND METHODS: This was a retrospective institutional review board-approved study of 97 patients who underwent liver MRI examinations with gadoxetate disodium and had no history of CLD. Available late dynamic and HP sequences (3-20 minutes postinjection) were independently analyzed by four radiologists for perceived image adequacy and level of biliary enhancement. Signal intensity ratios (SIRs) of liver/inferior vena cava (IVC), liver/spleen, and liver/muscle were measured. The Spearman ρ and receiver operating characteristic analyses were performed correlating various factors with HP adequacy. A rule for predicting HP adequacy was also derived and tested to determine whether overall examination time could be shortened. RESULTS: A visually adequate HP was observed in 12% of subjects by 10 minutes, 80% by 15 minutes, and 93% by 20 minutes. An SIRliver/IVC > 1.8 was the imaging feature that had the strongest correlation with an adequate HP (ρ = 0.813, P < .001), and was more predictive of adequacy of the HP than the time postinjection (ρ = 0.5, P < .001). The time at which an adequate HP was first observed did not correlate with any tested demographic or laboratory values. Stopping imaging when an SIRliver/IVC > 1.8 would have successfully reduced mean postcontrast time to 15:39 ± 4:02 from 20:00 (P < .001), although maintaining HP adequacy. CONCLUSIONS: Most patients without CLD undergoing gadoxetate-enhanced liver MRI achieve adequate HP at 20 minutes. However, a shorter postcontrast stopping time can be used in most patients.

Duke Scholars

Published In

Acad Radiol

DOI

EISSN

1878-4046

Publication Date

June 2014

Volume

21

Issue

6

Start / End Page

726 / 732

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Liver
  • Image Enhancement
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bashir, M. R., Breault, S. R., Braun, R., Do, R. K., Nelson, R. C., & Reeder, S. B. (2014). Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI. Acad Radiol, 21(6), 726–732. https://doi.org/10.1016/j.acra.2014.02.005
Bashir, Mustafa R., Steven R. Breault, Ryan Braun, Richard K. Do, Rendon C. Nelson, and Scott B. Reeder. “Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI.Acad Radiol 21, no. 6 (June 2014): 726–32. https://doi.org/10.1016/j.acra.2014.02.005.
Bashir MR, Breault SR, Braun R, Do RK, Nelson RC, Reeder SB. Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI. Acad Radiol. 2014 Jun;21(6):726–32.
Bashir, Mustafa R., et al. “Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI.Acad Radiol, vol. 21, no. 6, June 2014, pp. 726–32. Pubmed, doi:10.1016/j.acra.2014.02.005.
Bashir MR, Breault SR, Braun R, Do RK, Nelson RC, Reeder SB. Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI. Acad Radiol. 2014 Jun;21(6):726–732.
Journal cover image

Published In

Acad Radiol

DOI

EISSN

1878-4046

Publication Date

June 2014

Volume

21

Issue

6

Start / End Page

726 / 732

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Liver
  • Image Enhancement