Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Published

Journal Article

Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.

Full Text

Duke Authors

Cited Authors

  • Skouta, R; Dixon, SJ; Wang, J; Dunn, DE; Orman, M; Shimada, K; Rosenberg, PA; Lo, DC; Weinberg, JM; Linkermann, A; Stockwell, BR

Published Date

  • March 26, 2014

Published In

Volume / Issue

  • 136 / 12

Start / End Page

  • 4551 - 4556

PubMed ID

  • 24592866

Pubmed Central ID

  • 24592866

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

Digital Object Identifier (DOI)

  • 10.1021/ja411006a

Language

  • eng

Conference Location

  • United States