Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Published

Journal Article

Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.

Full Text

Cited Authors

  • Skouta, R; Dixon, SJ; Wang, J; Dunn, DE; Orman, M; Shimada, K; Rosenberg, PA; Lo, DC; Weinberg, JM; Linkermann, A; Stockwell, BR

Published Date

  • March 14, 2014

Published In

Volume / Issue

  • 136 / 12

Start / End Page

  • 4551 - 4556

PubMed ID

  • 24592866

Pubmed Central ID

  • 24592866

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja411006a

Language

  • eng