Clinical proton MR spectroscopy in central nervous system disorders.

Journal Article (Journal Article;Review)

A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of (1)H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of (1)H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which (1)H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.

Full Text

Duke Authors

Cited Authors

  • Oz, G; Alger, JR; Barker, PB; Bartha, R; Bizzi, A; Boesch, C; Bolan, PJ; Brindle, KM; Cudalbu, C; Dinçer, A; Dydak, U; Emir, UE; Frahm, J; González, RG; Gruber, S; Gruetter, R; Gupta, RK; Heerschap, A; Henning, A; Hetherington, HP; Howe, FA; Hüppi, PS; Hurd, RE; Kantarci, K; Klomp, DWJ; Kreis, R; Kruiskamp, MJ; Leach, MO; Lin, AP; Luijten, PR; Marjańska, M; Maudsley, AA; Meyerhoff, DJ; Mountford, CE; Nelson, SJ; Pamir, MN; Pan, JW; Peet, AC; Poptani, H; Posse, S; Pouwels, PJW; Ratai, E-M; Ross, BD; Scheenen, TW; Schuster, C; Smith, ICP; Soher, BJ; Tkáč, I; Vigneron, DB; Kauppinen, RA; MRS Consensus Group,

Published Date

  • March 2014

Published In

Volume / Issue

  • 270 / 3

Start / End Page

  • 658 - 679

PubMed ID

  • 24568703

Pubmed Central ID

  • PMC4263653

Electronic International Standard Serial Number (EISSN)

  • 1527-1315

Digital Object Identifier (DOI)

  • 10.1148/radiol.13130531


  • eng

Conference Location

  • United States