How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1.

Published

Journal Article

The copper transporter 1, Ctr1, is part of a major pathway for cellular copper (Cu) uptake in the intestinal epithelium, in hepatic and cardiac tissue, and likely in many other mammalian cells and tissues. Here, we summarize what is currently known about how extracellular Cu travels across the plasma membrane to enter the cytoplasm for intracellular distribution and for use by proteins and enzymes, the physiological roles of Ctr1, and its regulation. As a critical Cu importer, Ctr1 occupies a strategic position to exert a strong modifying influence on diseases and pathophysiological states caused by imbalances in Cu homeostasis. A more thorough understanding of the mechanisms that regulate Ctr1 abundance, trafficking, and function will provide new insights and opportunities for disease therapies.

Full Text

Duke Authors

Cited Authors

  • Ohrvik, H; Thiele, DJ

Published Date

  • May 2014

Published In

Volume / Issue

  • 1314 /

Start / End Page

  • 32 - 41

PubMed ID

  • 24697869

Pubmed Central ID

  • 24697869

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/nyas.12371

Language

  • eng

Conference Location

  • United States