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GABA level, gamma oscillation, and working memory performance in schizophrenia.

Publication ,  Journal Article
Chen, C-MA; Stanford, AD; Mao, X; Abi-Dargham, A; Shungu, DC; Lisanby, SH; Schroeder, CE; Kegeles, LS
Published in: Neuroimage Clin
2014

A relationship between working memory impairment, disordered neuronal oscillations, and abnormal prefrontal GABA function has been hypothesized in schizophrenia; however, in vivo GABA measurements and gamma band neural synchrony have not yet been compared in schizophrenia. This case-control pilot study (N = 24) compared baseline and working memory task-induced neuronal oscillations acquired with high-density electroencephalograms (EEGs) to GABA levels measured in vivo with magnetic resonance spectroscopy. Working memory performance, baseline GABA level in the left dorsolateral prefrontal cortex (DLPFC), and measures of gamma oscillations from EEGs at baseline and during a working memory task were obtained. A major limitation of this study is a relatively small sample size for several analyses due to the integration of diverse methodologies and participant compliance. Working memory performance was significantly lower for patients than for controls. During the working memory task, patients (n = 7) had significantly lower amplitudes in gamma oscillations than controls (n = 9). However, both at rest and across working memory stages, there were significant correlations between gamma oscillation amplitude and left DLPFC GABA level. Peak gamma frequency during the encoding stage of the working memory task (n = 16) significantly correlated with GABA level and working memory performance. Despite gamma band amplitude deficits in patients across working memory stages, both baseline and working memory-induced gamma oscillations showed strong dependence on baseline GABA levels in patients and controls. These findings suggest a critical role for GABA function in gamma band oscillations, even under conditions of system and cognitive impairments as seen in schizophrenia.

Duke Scholars

Published In

Neuroimage Clin

DOI

ISSN

2213-1582

Publication Date

2014

Volume

4

Start / End Page

531 / 539

Location

Netherlands

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Young Adult
  • Schizophrenia
  • Middle Aged
  • Memory, Short-Term
  • Male
  • Magnetic Resonance Spectroscopy
  • Humans
  • Gamma Rhythm
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, C.-M., Stanford, A. D., Mao, X., Abi-Dargham, A., Shungu, D. C., Lisanby, S. H., … Kegeles, L. S. (2014). GABA level, gamma oscillation, and working memory performance in schizophrenia. Neuroimage Clin, 4, 531–539. https://doi.org/10.1016/j.nicl.2014.03.007
Chen, Chi-Ming A., Arielle D. Stanford, Xiangling Mao, Anissa Abi-Dargham, Dikoma C. Shungu, Sarah H. Lisanby, Charles E. Schroeder, and Lawrence S. Kegeles. “GABA level, gamma oscillation, and working memory performance in schizophrenia.Neuroimage Clin 4 (2014): 531–39. https://doi.org/10.1016/j.nicl.2014.03.007.
Chen C-MA, Stanford AD, Mao X, Abi-Dargham A, Shungu DC, Lisanby SH, et al. GABA level, gamma oscillation, and working memory performance in schizophrenia. Neuroimage Clin. 2014;4:531–9.
Chen, Chi-Ming A., et al. “GABA level, gamma oscillation, and working memory performance in schizophrenia.Neuroimage Clin, vol. 4, 2014, pp. 531–39. Pubmed, doi:10.1016/j.nicl.2014.03.007.
Chen C-MA, Stanford AD, Mao X, Abi-Dargham A, Shungu DC, Lisanby SH, Schroeder CE, Kegeles LS. GABA level, gamma oscillation, and working memory performance in schizophrenia. Neuroimage Clin. 2014;4:531–539.
Journal cover image

Published In

Neuroimage Clin

DOI

ISSN

2213-1582

Publication Date

2014

Volume

4

Start / End Page

531 / 539

Location

Netherlands

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Young Adult
  • Schizophrenia
  • Middle Aged
  • Memory, Short-Term
  • Male
  • Magnetic Resonance Spectroscopy
  • Humans
  • Gamma Rhythm
  • Female