Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis.

Published

Journal Article

Calcineurin signaling plays diverse roles in fungi in regulating stress responses, morphogenesis and pathogenesis. Although calcineurin signaling is conserved among fungi, recent studies indicate important divergences in calcineurin-dependent cellular functions among different human fungal pathogens. Fungal pathogens utilize the calcineurin pathway to effectively survive the host environment and cause life-threatening infections. The immunosuppressive calcineurin inhibitors (FK506 and cyclosporine A) are active against fungi, making targeting calcineurin a promising antifungal drug development strategy. Here we summarize current knowledge on calcineurin in yeasts and filamentous fungi, and review the importance of understanding fungal-specific attributes of calcineurin to decipher fungal pathogenesis and develop novel antifungal therapeutic approaches.

Full Text

Duke Authors

Cited Authors

  • Juvvadi, PR; Lamoth, F; Steinbach, WJ

Published Date

  • October 2014

Published In

Volume / Issue

  • 28 / 2-3

Start / End Page

  • 56 - 69

PubMed ID

  • 25383089

Pubmed Central ID

  • 25383089

International Standard Serial Number (ISSN)

  • 1749-4613

Digital Object Identifier (DOI)

  • 10.1016/j.fbr.2014.02.004

Language

  • eng

Conference Location

  • Netherlands