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Relationship between human chorionic gonadotropin serum levels and the risk of ovarian hyperstimulation syndrome.

Publication ,  Journal Article
Johnson, MD; Williams, SL; Seager, CK; Liu, JH; Barker, NM; Hurd, WW
Published in: Gynecol Endocrinol
April 2014

The object of this retrospective cohort study was to determine if hCG levels correlate with ovarian hyperstimulation syndrome (OHSS) risk after adjustment for other risk factors during in vitro fertilization (IVF). We measured serum hCG approximately 12 h after hCG trigger in women undergoing 406 cycles of controlled ovarian hyperstimulation for IVF between June 2006 and December 2009. Serum hCG levels were measured 12 h after trigger. Bivariate logistic regression was used to assess the association between patient and cycle characteristics and OHSS. In our series, mild to moderate OHSS occurred in 9% (38/406), and severe OHSS diagnosed in 1.5% (6/406) of IVF cycles. OHSS risk was increased in younger women (<30 years old: adjusted odds ratio: aOR 2.46, 95% confidence interval: CI 1.14-5.34), increased number of oocytes (11-20: aOR 6.79, 95% CI 1.97-23.40; >20: aOR 17.55, 95% CI 4.84-63.70), and increase E2 levels (≥3,000 pg/mL: aOR 2.59, 95% CI 1.33-5.05), but was unrelated to hCG level (100-200 IU/L: aOR 1.53, 95% CI 0.60-3.91; ≥200 IU/L: aOR 1.42 95% CI 0.48-4.20). These results indicate that OHSS risk during IVF is unrelated to serum hCG level measured approximately 12 h after trigger.

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Published In

Gynecol Endocrinol

DOI

EISSN

1473-0766

Publication Date

April 2014

Volume

30

Issue

4

Start / End Page

294 / 297

Location

England

Related Subject Headings

  • Ultrasonography
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Ovulation Induction
  • Ovarian Hyperstimulation Syndrome
  • Obstetrics & Reproductive Medicine
  • Humans
  • Fertilization in Vitro
  • Female
 

Citation

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Johnson, M. D., Williams, S. L., Seager, C. K., Liu, J. H., Barker, N. M., & Hurd, W. W. (2014). Relationship between human chorionic gonadotropin serum levels and the risk of ovarian hyperstimulation syndrome. Gynecol Endocrinol, 30(4), 294–297. https://doi.org/10.3109/09513590.2013.875998
Johnson, Matrika D., Sanithia L. Williams, Christopher K. Seager, James H. Liu, Nichole M. Barker, and William W. Hurd. “Relationship between human chorionic gonadotropin serum levels and the risk of ovarian hyperstimulation syndrome.Gynecol Endocrinol 30, no. 4 (April 2014): 294–97. https://doi.org/10.3109/09513590.2013.875998.
Johnson MD, Williams SL, Seager CK, Liu JH, Barker NM, Hurd WW. Relationship between human chorionic gonadotropin serum levels and the risk of ovarian hyperstimulation syndrome. Gynecol Endocrinol. 2014 Apr;30(4):294–7.
Johnson, Matrika D., et al. “Relationship between human chorionic gonadotropin serum levels and the risk of ovarian hyperstimulation syndrome.Gynecol Endocrinol, vol. 30, no. 4, Apr. 2014, pp. 294–97. Pubmed, doi:10.3109/09513590.2013.875998.
Johnson MD, Williams SL, Seager CK, Liu JH, Barker NM, Hurd WW. Relationship between human chorionic gonadotropin serum levels and the risk of ovarian hyperstimulation syndrome. Gynecol Endocrinol. 2014 Apr;30(4):294–297.

Published In

Gynecol Endocrinol

DOI

EISSN

1473-0766

Publication Date

April 2014

Volume

30

Issue

4

Start / End Page

294 / 297

Location

England

Related Subject Headings

  • Ultrasonography
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Ovulation Induction
  • Ovarian Hyperstimulation Syndrome
  • Obstetrics & Reproductive Medicine
  • Humans
  • Fertilization in Vitro
  • Female