Characterizing individual differences in functional connectivity using dual-regression and seed-based approaches.

Published

Journal Article

A central challenge for neuroscience lies in relating inter-individual variability to the functional properties of specific brain regions. Yet, considerable variability exists in the connectivity patterns between different brain areas, potentially producing reliable group differences. Using sex differences as a motivating example, we examined two separate resting-state datasets comprising a total of 188 human participants. Both datasets were decomposed into resting-state networks (RSNs) using a probabilistic spatial independent component analysis (ICA). We estimated voxel-wise functional connectivity with these networks using a dual-regression analysis, which characterizes the participant-level spatiotemporal dynamics of each network while controlling for (via multiple regression) the influence of other networks and sources of variability. We found that males and females exhibit distinct patterns of connectivity with multiple RSNs, including both visual and auditory networks and the right frontal-parietal network. These results replicated across both datasets and were not explained by differences in head motion, data quality, brain volume, cortisol levels, or testosterone levels. Importantly, we also demonstrate that dual-regression functional connectivity is better at detecting inter-individual variability than traditional seed-based functional connectivity approaches. Our findings characterize robust-yet frequently ignored-neural differences between males and females, pointing to the necessity of controlling for sex in neuroscience studies of individual differences. Moreover, our results highlight the importance of employing network-based models to study variability in functional connectivity.

Full Text

Duke Authors

Cited Authors

  • Smith, DV; Utevsky, AV; Bland, AR; Clement, N; Clithero, JA; Harsch, AEW; McKell Carter, R; Huettel, SA

Published Date

  • July 2014

Published In

Volume / Issue

  • 95 /

Start / End Page

  • 1 - 12

PubMed ID

  • 24662574

Pubmed Central ID

  • 24662574

Electronic International Standard Serial Number (EISSN)

  • 1095-9572

International Standard Serial Number (ISSN)

  • 1053-8119

Digital Object Identifier (DOI)

  • 10.1016/j.neuroimage.2014.03.042

Language

  • eng