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Accuracy of contrast-enhanced dual-energy MDCT for the assessment of iodine uptake in renal lesions.

Publication ,  Journal Article
Mileto, A; Marin, D; Ramirez-Giraldo, JC; Scribano, E; Krauss, B; Mazziotti, S; Ascenti, G
Published in: AJR Am J Roentgenol
May 2014

OBJECTIVE: The objective of our study was to assess the accuracy of iodine-related attenuation and iodine quantification as imaging biomarkers of iodine uptake in renal lesions on a single-phase nephrographic image with dual-energy MDCT. MATERIALS AND METHODS: Fifty-nine patients (41 men, 18 women; age range, 28-84 years) with 80 renal lesions underwent contrast-enhanced dual-energy CT during the nephrographic phase of enhancement. Renal lesions were characterized as enhancing or nonenhancing on color-coded iodine overlay maps using iodine-related attenuation (in Hounsfield units) and iodine quantification (in milligrams per milliliter). For iodine-related attenuation the iodine uptake thresholds of 15 and 20 HU were tested; a threshold of 0.5 mg/mL was used for iodine quantification. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of iodine-related attenuation and iodine quantification were calculated from chi-square tests of contingency with histopathology or imaging follow-up as the reference standard. The 95% CIs were calculated from binomial expression. Differences in sensitivity and specificity were assessed by means of McNemar analysis. RESULTS: A significant difference in sensitivity and specificity was found between iodine-related attenuation with the thresholds of 15 HU (sensitivity, 91.4%; specificity, 93.3%; PPV, 91.4%; NPV, 93.3%) and 20 HU (sensitivity, 77.1%; specificity, 100%; PPV, 100%; NPV, 84.9%) (p = 0.008) and between iodine quantification (sensitivity, 100%; specificity, 97.7%; PPV, 97.2%; NPV, 100%) and iodine-related attenuation with a threshold of 20 HU (p = 0.004). No significant difference in sensitivity and specificity was found between iodine quantification and iodine-related attenuation with a threshold of 15 HU. CONCLUSION: Contrast-enhanced dual-energy MDCT with iodine-related attenuation and iodine quantification allows accurate evaluation of iodine uptake in renal lesions on a single-phase nephrographic image.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

May 2014

Volume

202

Issue

5

Start / End Page

W466 / W474

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Multidetector Computed Tomography
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Iodine
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Mileto, A., Marin, D., Ramirez-Giraldo, J. C., Scribano, E., Krauss, B., Mazziotti, S., & Ascenti, G. (2014). Accuracy of contrast-enhanced dual-energy MDCT for the assessment of iodine uptake in renal lesions. AJR Am J Roentgenol, 202(5), W466–W474. https://doi.org/10.2214/AJR.13.11450
Mileto, Achille, Daniele Marin, Juan Carlos Ramirez-Giraldo, Emanuele Scribano, Bernhard Krauss, Silvio Mazziotti, and Giorgio Ascenti. “Accuracy of contrast-enhanced dual-energy MDCT for the assessment of iodine uptake in renal lesions.AJR Am J Roentgenol 202, no. 5 (May 2014): W466–74. https://doi.org/10.2214/AJR.13.11450.
Mileto A, Marin D, Ramirez-Giraldo JC, Scribano E, Krauss B, Mazziotti S, et al. Accuracy of contrast-enhanced dual-energy MDCT for the assessment of iodine uptake in renal lesions. AJR Am J Roentgenol. 2014 May;202(5):W466–74.
Mileto, Achille, et al. “Accuracy of contrast-enhanced dual-energy MDCT for the assessment of iodine uptake in renal lesions.AJR Am J Roentgenol, vol. 202, no. 5, May 2014, pp. W466–74. Pubmed, doi:10.2214/AJR.13.11450.
Mileto A, Marin D, Ramirez-Giraldo JC, Scribano E, Krauss B, Mazziotti S, Ascenti G. Accuracy of contrast-enhanced dual-energy MDCT for the assessment of iodine uptake in renal lesions. AJR Am J Roentgenol. 2014 May;202(5):W466–W474.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

May 2014

Volume

202

Issue

5

Start / End Page

W466 / W474

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Multidetector Computed Tomography
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Iodine
  • Humans
  • Female