Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy?

Journal Article (Journal Article;Review)

In a growing outpatient surgical population, postdischarge nausea and vomiting (PDNV) is unfortunately a common and costly anesthetic complication. Identification of risk factors for both postoperative nausea and vomiting and PDNV is the hallmark of prevention and management. New pharmacologic interventions with extended duration of action, including palonosetron and aprepritant, may prove to be more efficacious.

Full Text

Duke Authors

Cited Authors

  • Melton, MS; Nielsen, KC; Tucker, M; Klein, SM; Gan, TJ

Published Date

  • June 2014

Published In

Volume / Issue

  • 32 / 2

Start / End Page

  • 505 - 516

PubMed ID

  • 24882134

International Standard Serial Number (ISSN)

  • 1932-2275

Digital Object Identifier (DOI)

  • 10.1016/j.anclin.2014.02.004


  • eng

Conference Location

  • United States