Cellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis.

Journal Article (Journal Article;Review)

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by severe and progressive scar formation in the gas-exchange regions of the lung. Despite years of research, therapeutic treatments remain elusive and there is a pressing need for deeper mechanistic insights into the pathogenesis of the disease. In this article, we review our current knowledge of the triggers and/or perpetuators of pulmonary fibrosis with special emphasis on the alveolar epithelium and the underlying mesenchyme. In doing so, we raise a number of questions highlighting critical voids and limitations in our current understanding and study of this disease.

Full Text

Duke Authors

Cited Authors

  • Barkauskas, CE; Noble, PW

Published Date

  • June 1, 2014

Published In

Volume / Issue

  • 306 / 11

Start / End Page

  • C987 - C996

PubMed ID

  • 24740535

Pubmed Central ID

  • PMC4422352

Electronic International Standard Serial Number (EISSN)

  • 1522-1563

Digital Object Identifier (DOI)

  • 10.1152/ajpcell.00321.2013


  • eng

Conference Location

  • United States