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Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.

Publication ,  Journal Article
Li, Z; Ding, Q; Li, Y; Miller, SA; Abbruzzese, JL; Hung, M-C
Published in: Cancer Lett
May 8, 2006

Pancreatic cancer is highly aggressive with extremely poor prognosis. Developing a pancreatic cancer specific promoter (PCSP) is one approach for pancreatic cancer gene therapy. We have modified the promoter of cholecystokinin type A receptor (CCKAR), named CCK/Mpd, which possesses a relatively high activity in pancreatic cancer cells as compared with normal cells. The CCK/Mpd promoter-driven luciferase exhibits a better tumor specific tissue distribution than the CMV promoter-driven luciferase when systemically administered in vivo. Notably, we demonstrate a treatment efficacy by using CCK/Mpd-Bik-DD/liposome in a nude mice xenograft model, suggesting the feasibility of PCSP-based gene therapy in pancreatic cancer treatment.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

May 8, 2006

Volume

236

Issue

1

Start / End Page

58 / 63

Location

Ireland

Related Subject Headings

  • Transfection
  • Tissue Distribution
  • Receptor, Cholecystokinin A
  • Promoter Regions, Genetic
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mutation
  • Mice, Nude
  • Mice
 

Citation

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MLA
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Li, Z., Ding, Q., Li, Y., Miller, S. A., Abbruzzese, J. L., & Hung, M.-C. (2006). Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett, 236(1), 58–63. https://doi.org/10.1016/j.canlet.2005.05.001
Li, Zheng, Qingqing Ding, Yan Li, Stephanie A. Miller, James L. Abbruzzese, and Mien-Chie Hung. “Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.Cancer Lett 236, no. 1 (May 8, 2006): 58–63. https://doi.org/10.1016/j.canlet.2005.05.001.
Li Z, Ding Q, Li Y, Miller SA, Abbruzzese JL, Hung M-C. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 2006 May 8;236(1):58–63.
Li, Zheng, et al. “Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.Cancer Lett, vol. 236, no. 1, May 2006, pp. 58–63. Pubmed, doi:10.1016/j.canlet.2005.05.001.
Li Z, Ding Q, Li Y, Miller SA, Abbruzzese JL, Hung M-C. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 2006 May 8;236(1):58–63.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

May 8, 2006

Volume

236

Issue

1

Start / End Page

58 / 63

Location

Ireland

Related Subject Headings

  • Transfection
  • Tissue Distribution
  • Receptor, Cholecystokinin A
  • Promoter Regions, Genetic
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mutation
  • Mice, Nude
  • Mice