NGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background.


Journal Article

M/KCNQ currents play a critical role in the determination of neuronal excitability. Many neurotransmitters and peptides modulate M/KCNQ current and neuronal excitability through their G protein-coupled receptors. Nerve growth factor (NGF) activates its receptor, a member of receptor tyrosine kinase (RTK) superfamily, and crucially modulates neuronal cell survival, proliferation, and differentiation. In this study, we studied the effect of NGF on the neuronal (rat superior cervical ganglion, SCG) M/KCNQ currents and excitability. As reported before, subpopulation SCG neurons with distinct firing properties could be classified into tonic, phasic-1, and phasic-2 neurons. NGF inhibited M/KCNQ currents by similar proportion in all three classes of SCG neurons but increased the excitability only significantly in tonic SCG neurons. The effect of NGF on excitability correlated with a smaller M-current density in tonic neurons. The present study indicates that NGF is an M/KCNQ channel modulator and the characteristic modulation of the neuronal excitability by NGF may have important physiological implications.

Full Text

Duke Authors

Cited Authors

  • Jia, Z; Bei, J; Rodat-Despoix, L; Liu, B; Jia, Q; Delmas, P; Zhang, H

Published Date

  • June 2008

Published In

Volume / Issue

  • 131 / 6

Start / End Page

  • 575 - 587

PubMed ID

  • 18474635

Pubmed Central ID

  • 18474635

Electronic International Standard Serial Number (EISSN)

  • 1540-7748

Digital Object Identifier (DOI)

  • 10.1085/jgp.200709924


  • eng

Conference Location

  • United States