Tumor acquisition for biomarker research in lung cancer.
Journal Article (Journal Article)
The biopsy collection data from two lung cancer trials that required fresh tumor samples be obtained for microarray analysis were reviewed. In the trial for advanced disease, microarray data were obtained on 50 patient samples, giving an overall success rate of 60.2%. The majority of the specimens were obtained through CT-guided lung biopsies (N = 30). In the trial for early-stage patients, 28 tissue specimens were collected from excess tumor after surgical resection with a success rate of 85.7%. This tissue procurement program documents the feasibility in obtaining fresh tumor specimens prospectively that could be used for molecular testing.
Full Text
Duke Authors
- Christensen, Jared Dean
- Crawford, Jeffrey
- D'Amico, Thomas Anthony
- Datto, Michael Bradley
- Ginsburg, Geoffrey Steven
- Ready, Neal Edward
- Shofer, Scott Leigh
- Stevenson, Marvaretta Miesha
- Tong, Betty Caroline
- Wahidi, Momen Mohammed
Cited Authors
- Stevenson, M; Christensen, J; Shoemaker, D; Foster, T; Barry, WT; Tong, BC; Wahidi, M; Shofer, S; Datto, M; Ginsburg, G; Crawford, J; D'Amico, T; Ready, N
Published Date
- July 2014
Published In
Volume / Issue
- 32 / 6
Start / End Page
- 291 - 298
PubMed ID
- 24810245
Pubmed Central ID
- PMC4336177
Electronic International Standard Serial Number (EISSN)
- 1532-4192
Digital Object Identifier (DOI)
- 10.3109/07357907.2014.911880
Language
- eng
Conference Location
- England