Measuring anxiety as a treatment endpoint in youth with autism spectrum disorder.

Journal Article (Journal Article;Review;Systematic Review)

Despite the high rate of anxiety in individuals with autism spectrum disorder (ASD), measuring anxiety in ASD is fraught with uncertainty. This is due, in part, to incomplete consensus on the manifestations of anxiety in this population. Autism Speaks assembled a panel of experts to conduct a systematic review of available measures for anxiety in youth with ASD. To complete the review, the panel held monthly conference calls and two face-to-face meetings over a fourteen-month period. Thirty eight published studies were reviewed and ten assessment measures were examined: four were deemed appropriate for use in clinical trials, although with conditions; three were judged to be potentially appropriate, while three were considered not useful for clinical trials assessing anxiety. Despite recent advances, additional relevant, reliable and valid outcome measures are needed to evaluate treatments for anxiety in ASD.

Full Text

Duke Authors

Cited Authors

  • Lecavalier, L; Wood, JJ; Halladay, AK; Jones, NE; Aman, MG; Cook, EH; Handen, BL; King, BH; Pearson, DA; Hallett, V; Sullivan, KA; Grondhuis, S; Bishop, SL; Horrigan, JP; Dawson, G; Scahill, L

Published Date

  • May 2014

Published In

Volume / Issue

  • 44 / 5

Start / End Page

  • 1128 - 1143

PubMed ID

  • 24158679

Pubmed Central ID

  • PMC3981870

Electronic International Standard Serial Number (EISSN)

  • 1573-3432

Digital Object Identifier (DOI)

  • 10.1007/s10803-013-1974-9


  • eng

Conference Location

  • United States