Chronic, wireless recordings of large-scale brain activity in freely moving rhesus monkeys.

Published

Journal Article

Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tethered and wireless large-scale recordings based on movable volumetric three-dimensional (3D) multielectrode implants. This approach allowed us to isolate up to 1,800 neurons (units) per animal and simultaneously record the extracellular activity of close to 500 cortical neurons, distributed across multiple cortical areas, in freely behaving rhesus monkeys. The method is expandable, in principle, to thousands of simultaneously recorded channels. It also allows increased recording longevity (5 consecutive years) and recording of a broad range of behaviors, such as social interactions, and BMI paradigms in freely moving primates. We propose that wireless large-scale recordings could have a profound impact on basic primate neurophysiology research while providing a framework for the development and testing of clinically relevant neuroprostheses.

Full Text

Duke Authors

Cited Authors

  • Schwarz, DA; Lebedev, MA; Hanson, TL; Dimitrov, DF; Lehew, G; Meloy, J; Rajangam, S; Subramanian, V; Ifft, PJ; Li, Z; Ramakrishnan, A; Tate, A; Zhuang, KZ; Nicolelis, MAL

Published Date

  • June 2014

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 670 - 676

PubMed ID

  • 24776634

Pubmed Central ID

  • 24776634

Electronic International Standard Serial Number (EISSN)

  • 1548-7105

Digital Object Identifier (DOI)

  • 10.1038/nmeth.2936

Language

  • eng

Conference Location

  • United States