Compressive mass analysis on quadrupole ion trap systems.


Journal Article

Conventionally, quadrupole ion trap mass spectrometers eject ions of different mass-to-charge ratio (m/z) in a sequential fashion by performing a scan of the rf trapping voltage amplitude. Due to the inherent sparsity of most mass spectra, the detector measures no signal for much of the scan time. By exploiting this sparsity property, we propose a new compressive and multiplexed mass analysis approach--multi Resonant Frequency Excitation (mRFE) ejection. This new approach divides the mass spectrum into several mass subranges and detects all the subrange spectra in parallel for increased mass analysis speed. Mathematical estimation of standard mass spectrum is demonstrated while statistical classification on the parallel measurements remains viable because of the sparse nature of the mass spectra. This method can reduce mass analysis time by a factor of 3-6 and increase system duty cycle by 2×. The combination of reduced analysis time and accurate compound classification is demonstrated in a commercial quadrupole ion trap (QIT) system.

Full Text

Duke Authors

Cited Authors

  • Chen, EX; Gehm, M; Danell, R; Wells, M; Glass, JT; Brady, D

Published Date

  • July 2014

Published In

Volume / Issue

  • 25 / 7

Start / End Page

  • 1295 - 1304

PubMed ID

  • 24806048

Pubmed Central ID

  • 24806048

Electronic International Standard Serial Number (EISSN)

  • 1879-1123

International Standard Serial Number (ISSN)

  • 1044-0305

Digital Object Identifier (DOI)

  • 10.1007/s13361-014-0894-z


  • eng