Magnetophoretic circuits for digital control of single particles and cells

Journal Article (Academic article)

The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.

Full Text

Duke Authors

Cited Authors

  • Lim, B; Reddy, V; Hu, X; Kim, K; Jadhav, M; Abedini-Nassab, R; Noh, Y; Lim, YT; Yellen, BB; Kim, C

Published Date

  • May 14, 2014

Published In

  • Nature Communications

Volume / Issue

  • 5 /

Published By

PubMed ID

  • 24828763

Digital Object Identifier (DOI)

  • 10.1038/ncomms4846