Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.

Published

Journal Article

Subglutinol A (1) is an immunosuppressive natural product isolated from Fusarium subglutinans, an endophytic fungus from the vine Tripterygium wilfordii. We show that 1 exerts multimodal immune-suppressive effects on activated T cells in vitro: subglutinol A (1) effectively blocks T cell proliferation and survival while profoundly inhibiting pro-inflammatory IFNγ and IL-17 production by fully differentiated effector Th1 and Th17 cells. Our data further reveal that 1 may exert its anti-inflammatory effects by exacerbating mitochondrial damage in T cells. Additionally, we demonstrate that 1 significantly reduces lymphocytic infiltration into the footpad and ameliorates footpad swelling in the mouse model of Th1-driven delayed-type hypersensitivity. These results suggest the potential of 1 as a novel therapeutic for inflammatory diseases.

Full Text

Duke Authors

Cited Authors

  • Lin, R; Kim, H; Hong, J; Li, Q-J

Published Date

  • May 2014

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 485 - 490

PubMed ID

  • 24900866

Pubmed Central ID

  • 24900866

Electronic International Standard Serial Number (EISSN)

  • 1948-5875

International Standard Serial Number (ISSN)

  • 1948-5875

Digital Object Identifier (DOI)

  • 10.1021/ml4004809

Language

  • eng