Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
Journal Article (Journal Article)
Subglutinol A (1) is an immunosuppressive natural product isolated from Fusarium subglutinans, an endophytic fungus from the vine Tripterygium wilfordii. We show that 1 exerts multimodal immune-suppressive effects on activated T cells in vitro: subglutinol A (1) effectively blocks T cell proliferation and survival while profoundly inhibiting pro-inflammatory IFNγ and IL-17 production by fully differentiated effector Th1 and Th17 cells. Our data further reveal that 1 may exert its anti-inflammatory effects by exacerbating mitochondrial damage in T cells. Additionally, we demonstrate that 1 significantly reduces lymphocytic infiltration into the footpad and ameliorates footpad swelling in the mouse model of Th1-driven delayed-type hypersensitivity. These results suggest the potential of 1 as a novel therapeutic for inflammatory diseases.
Full Text
Duke Authors
Cited Authors
- Lin, R; Kim, H; Hong, J; Li, Q-J
Published Date
- May 8, 2014
Published In
Volume / Issue
- 5 / 5
Start / End Page
- 485 - 490
PubMed ID
- 24900866
Pubmed Central ID
- 24900866
International Standard Serial Number (ISSN)
- 1948-5875
Digital Object Identifier (DOI)
- 10.1021/ml4004809
Language
- eng
Conference Location
- United States