Perception of the plant immune signal salicylic acid.


Journal Article (Review)

Salicylic acid (SA) plays a central role in plant innate immunity. The diverse functions of this simple phenolic compound suggest that plants may have multiple SA receptors. Several SA-binding proteins have been identified using biochemical approaches. However, genetic evidence supporting that they are the bona fide SA receptors has not been forthcoming. Mutant screens revealed that NPR1 is a master regulator of SA-mediated responses. Although NPR1 cannot bind SA in a conventional ligand-binding assay, its homologs NPR3 and NPR4 bind SA and function as SA receptors. During pathogen challenge, the SA gradient generated at the infection site is sensed by NPR3 and NPR4, which serve as the adaptors for the Cullin 3-based E3 ubiquitin ligase to regulate NPR1 degradation. Consequently, NPR1 is degraded at the infection site to remove its inhibition on effector-triggered cell death and defense, whereas NPR1 accumulates in neighboring cells to promote cell survival and SA-mediated resistance.

Full Text

Duke Authors

Cited Authors

  • Yan, S; Dong, X

Published Date

  • August 2014

Published In

Volume / Issue

  • 20 /

Start / End Page

  • 64 - 68

PubMed ID

  • 24840293

Pubmed Central ID

  • 24840293

Electronic International Standard Serial Number (EISSN)

  • 1879-0356

International Standard Serial Number (ISSN)

  • 1369-5266

Digital Object Identifier (DOI)

  • 10.1016/j.pbi.2014.04.006


  • eng