Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection.

Journal Article (Journal Article)

An effective HIV-1 vaccine should elicit sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus. Evaluation of the breadth and magnitude of cellular immune responses to epitope variants is important for HIV-1 vaccine assessment. We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.

Full Text

Duke Authors

Cited Authors

  • Giorgi, EE; Balachandran, H; Muldoon, M; Letvin, NL; Haynes, BF; Korber, BT; Santra, S

Published Date

  • June 30, 2014

Published In

Volume / Issue

  • 32 / 31

Start / End Page

  • 3995 - 4000

PubMed ID

  • 24837783

Pubmed Central ID

  • PMC4084750

Electronic International Standard Serial Number (EISSN)

  • 1873-2518

Digital Object Identifier (DOI)

  • 10.1016/j.vaccine.2014.04.040


  • eng

Conference Location

  • Netherlands