Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection.
Journal Article (Journal Article)
An effective HIV-1 vaccine should elicit sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus. Evaluation of the breadth and magnitude of cellular immune responses to epitope variants is important for HIV-1 vaccine assessment. We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.
Full Text
Duke Authors
Cited Authors
- Giorgi, EE; Balachandran, H; Muldoon, M; Letvin, NL; Haynes, BF; Korber, BT; Santra, S
Published Date
- June 30, 2014
Published In
Volume / Issue
- 32 / 31
Start / End Page
- 3995 - 4000
PubMed ID
- 24837783
Pubmed Central ID
- PMC4084750
Electronic International Standard Serial Number (EISSN)
- 1873-2518
Digital Object Identifier (DOI)
- 10.1016/j.vaccine.2014.04.040
Language
- eng
Conference Location
- Netherlands