Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system

Journal Article

Background: Nucleotide excision repair and the ATR-mediated DNA damage checkpoint responses are genetically coupled. Results: We have analyzed the basic steps of ATR activation in a biochemically defined system. Conclusion: ATR signaling requires enlargement of the DNA excision gap by EXO1. Significance: The six excision repair factors, ATR-ATRIP, TopBP1, and EXO1 constitute the minimum essential set of proteins for ATR-activation upon UV-induced DNA damage. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Full Text

Duke Authors

Cited Authors

  • Lindsey-Boltz, LA; Kemp, MG; Reardon, JT; DeRocco, V; Iyer, RR; Modrich, P; Sancar, A

Published Date

  • 2014

Published In

Volume / Issue

  • 289 / 8

Start / End Page

  • 5074 - 5082

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M113.542787