Testosterone reactivity to provocation mediates the effect of early intervention on aggressive behavior.

Journal Article (Journal Article)

We tested the hypotheses that the Fast Track intervention program for high-risk children would reduce adult aggressive behavior and that this effect would be mediated by decreased testosterone responses to social provocation. Participants were a subsample of males from the full trial sample, who during kindergarten had been randomly assigned to the 10-year Fast Track intervention or to a control group. The Fast Track program attempted to develop children's social competencies through child social-cognitive and emotional-coping skills training, peer-relations coaching, academic tutoring, and classroom management, as well as training for parents to manage their child's behavior. At a mean age of 26 years, participants responded to laboratory provocations. Results indicated that, relative to control participants, men assigned to the intervention demonstrated reduced aggression and testosterone reactivity to social provocations. Moreover, reduced testosterone reactivity mediated the effect of intervention on aggressive behavior, which provides evidence for an enduring biological mechanism underlying the effect of early psychosocial intervention on aggressive behavior in adulthood.

Full Text

Duke Authors

Cited Authors

  • Carré, JM; Iselin, A-MR; Welker, KM; Hariri, AR; Dodge, KA

Published Date

  • May 2014

Published In

Volume / Issue

  • 25 / 5

Start / End Page

  • 1140 - 1146

PubMed ID

  • 24681586

Pubmed Central ID

  • PMC4278576

Electronic International Standard Serial Number (EISSN)

  • 1467-9280

International Standard Serial Number (ISSN)

  • 0956-7976

Digital Object Identifier (DOI)

  • 10.1177/0956797614525642


  • eng