Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne
Journal Article (Journal Article)
An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.
Full Text
Duke Authors
Cited Authors
- Jones, GB; Kilgore, MW; Pollenz, RS; Li, A; Mathews, JE; Wright, JM; Huber, RS; Tate, PL; Price, TL; Sticca, RP
Published Date
- August 20, 1996
Published In
Volume / Issue
- 6 / 16
Start / End Page
- 1971 - 1976
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/0960-894X(96)00352-6
Citation Source
- Scopus