Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne
An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.
Jones, GB; Kilgore, MW; Pollenz, RS; Li, A; Mathews, JE; Wright, JM; Huber, RS; Tate, PL; Price, TL; Sticca, RP
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