Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

Journal Article (Journal Article)

An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed.

Full Text

Duke Authors

Cited Authors

  • Jones, GB; Kilgore, MW; Pollenz, RS; Li, A; Mathews, JE; Wright, JM; Huber, RS; Tate, PL; Price, TL; Sticca, RP

Published Date

  • August 20, 1996

Published In

Volume / Issue

  • 6 / 16

Start / End Page

  • 1971 - 1976

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/0960-894X(96)00352-6

Citation Source

  • Scopus