CT angiography after 20 years: a transformation in cardiovascular disease characterization continues to advance.

Journal Article (Journal Article;Review)

Through a marriage of spiral computed tomography (CT) and graphical volumetric image processing, CT angiography was born 20 years ago. Fueled by a series of technical innovations in CT and image processing, over the next 5-15 years, CT angiography toppled conventional angiography, the undisputed diagnostic reference standard for vascular disease for the prior 70 years, as the preferred modality for the diagnosis and characterization of most cardiovascular abnormalities. This review recounts the evolution of CT angiography from its development and early challenges to a maturing modality that has provided unique insights into cardiovascular disease characterization and management. Selected clinical challenges, which include acute aortic syndromes, peripheral vascular disease, aortic stent-graft and transcatheter aortic valve assessment, and coronary artery disease, are presented as contrasting examples of how CT angiography is changing our approach to cardiovascular disease diagnosis and management. Finally, the recently introduced capabilities for multispectral imaging, tissue perfusion imaging, and radiation dose reduction through iterative reconstruction are explored with consideration toward the continued refinement and advancement of CT angiography.

Full Text

Duke Authors

Cited Authors

  • Rubin, GD; Leipsic, J; Joseph Schoepf, U; Fleischmann, D; Napel, S

Published Date

  • June 2014

Published In

Volume / Issue

  • 271 / 3

Start / End Page

  • 633 - 652

PubMed ID

  • 24848958

Pubmed Central ID

  • PMC4669887

Electronic International Standard Serial Number (EISSN)

  • 1527-1315

Digital Object Identifier (DOI)

  • 10.1148/radiol.14132232


  • eng

Conference Location

  • United States