The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats--animal models of alcoholism.

Published

Journal Article (Review)

The objective of this article is to review the literature on the utility of using the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) lines of rats in studies examining high alcohol drinking in adults and adolescents, craving-like behavior, and the co-abuse of alcohol with other drugs. The P line of rats meets all of the originally proposed criteria for a suitable animal model of alcoholism. In addition, the P rat exhibits high alcohol-seeking behavior, demonstrates an alcohol deprivation effect (ADE) under relapse drinking conditions, consumes amounts of ethanol during adolescence equivalent to those consumed in adulthood, and co-abuses ethanol and nicotine. The P line also exhibits excessive binge-like alcohol drinking, attaining blood alcohol concentrations (BACs) of 200 mg% on a daily basis. The HAD replicate lines of rats have not been as extensively studied as the P rats. The HAD1,2 rats satisfy several of the criteria for an animal model of alcoholism, e.g., these rats will voluntarily consume ethanol in a free-choice situation to produce BACs between 50 and 200 mg%. The HAD1,2 rats also exhibit an ADE under repeated relapse conditions, and will demonstrate similar levels of ethanol intake during adolescence as seen in adults. Overall, the P and HAD1,2 rats have characteristics attributed to an early onset alcoholic, and can be used to study various aspects of alcohol use disorders.

Full Text

Cited Authors

  • McBride, WJ; Rodd, ZA; Bell, RL; Lumeng, L; Li, T-K

Published Date

  • May 2014

Published In

Volume / Issue

  • 48 / 3

Start / End Page

  • 209 - 215

PubMed ID

  • 24268381

Pubmed Central ID

  • 24268381

Electronic International Standard Serial Number (EISSN)

  • 1873-6823

Digital Object Identifier (DOI)

  • 10.1016/j.alcohol.2013.09.044

Language

  • eng

Conference Location

  • United States