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Prognosis and delay of diagnosis among Kaposi's sarcoma patients in Uganda: a cross-sectional study.

Publication ,  Journal Article
De Boer, C; Niyonzima, N; Orem, J; Bartlett, J; Zafar, SY
Published in: Infect Agent Cancer
2014

BACKGROUND: In low- and middle-income countries, the association between delay to treatment and prognosis for Kaposi's sarcoma (KS) patients is yet to be studied. METHODS: This is a prospective study of HIV-infected adults with histologically-confirmed KS treated at the Uganda Cancer Institute (UCI). Standardized interviews were conducted in English or Luganda. Medical records were abstracted for KS stage at admission to UCI. Multivariable logistic regression assessed relationships between diagnostic delay and stage at diagnosis. RESULTS: Of 161 patients (90% response rate), 69% were men, and the mean age was 34.0 years (SD 7.7). 26% had been seen in an HIV clinic within 3 months, 72% were on antiretroviral therapy, and 26% had visited a traditional healer prior to diagnosis. 45% delayed seeking care at UCI for ≥3 months from symptom onset. Among those who delayed, 36% waited 6 months, and 25% waited 12 months. Common reasons for delay were lack of pain (48%), no money (32%), and distance to UCI (8%). In adjusted analysis patients who experienced diagnostic delay were more likely than those who did not delay to have poor-risk KS stage (OR 3.41, p = 0.002, 95% CI: 1.46-7.45). In adjusted analyses visiting a traditional healer was the only variable associated with greater likelihood of delay (OR 2.69, p = 0.020, 95% CI: 1.17-6.17). CONCLUSIONS: Diagnostic delay was associated with poor-risk stage at diagnosis, and visiting a traditional healer was associated with higher odds of delay. The relationship between traditional and Western medicine presents a critical intervention point to improve KS-related outcomes in Uganda.

Duke Scholars

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Published In

Infect Agent Cancer

DOI

ISSN

1750-9378

Publication Date

2014

Volume

9

Start / End Page

17

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1108 Medical Microbiology
 

Citation

APA
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De Boer, C., Niyonzima, N., Orem, J., Bartlett, J., & Zafar, S. Y. (2014). Prognosis and delay of diagnosis among Kaposi's sarcoma patients in Uganda: a cross-sectional study. Infect Agent Cancer, 9, 17. https://doi.org/10.1186/1750-9378-9-17
De Boer, Christopher, Nixon Niyonzima, Jackson Orem, John Bartlett, and S Yousuf Zafar. “Prognosis and delay of diagnosis among Kaposi's sarcoma patients in Uganda: a cross-sectional study.Infect Agent Cancer 9 (2014): 17. https://doi.org/10.1186/1750-9378-9-17.
De Boer C, Niyonzima N, Orem J, Bartlett J, Zafar SY. Prognosis and delay of diagnosis among Kaposi's sarcoma patients in Uganda: a cross-sectional study. Infect Agent Cancer. 2014;9:17.
De Boer, Christopher, et al. “Prognosis and delay of diagnosis among Kaposi's sarcoma patients in Uganda: a cross-sectional study.Infect Agent Cancer, vol. 9, 2014, p. 17. Pubmed, doi:10.1186/1750-9378-9-17.
De Boer C, Niyonzima N, Orem J, Bartlett J, Zafar SY. Prognosis and delay of diagnosis among Kaposi's sarcoma patients in Uganda: a cross-sectional study. Infect Agent Cancer. 2014;9:17.
Journal cover image

Published In

Infect Agent Cancer

DOI

ISSN

1750-9378

Publication Date

2014

Volume

9

Start / End Page

17

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1108 Medical Microbiology