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Sequential roles of Hedgehog and Wnt signaling in osteoblast development.

Publication ,  Journal Article
Hu, H; Hilton, MJ; Tu, X; Yu, K; Ornitz, DM; Long, F
Published in: Development
January 2005

Signals that govern development of the osteoblast lineage are not well understood. Indian hedgehog (Ihh), a member of the hedgehog (Hh) family of proteins, is essential for osteogenesis in the endochondral skeleton during embryogenesis. The canonical pathway of Wnt signaling has been implicated by studies of Lrp5, a co-receptor for Wnt proteins, in postnatal bone mass homeostasis. In the present study we demonstrate that beta-catenin, a central player in the canonical Wnt pathway, is indispensable for osteoblast differentiation in the mouse embryo. Moreover, we present evidence that Wnt signaling functions downstream of Ihh in development of the osteoblast lineage. Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development.

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Published In

Development

DOI

ISSN

0950-1991

Publication Date

January 2005

Volume

132

Issue

1

Start / End Page

49 / 60

Location

England

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Trans-Activators
  • Time Factors
  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Retroviridae
  • Receptors, LDL
  • Proto-Oncogene Proteins
  • Osteoblasts
 

Citation

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Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005). Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development, 132(1), 49–60. https://doi.org/10.1242/dev.01564
Hu, Hongliang, Matthew J. Hilton, Xiaolin Tu, Kai Yu, David M. Ornitz, and Fanxin Long. “Sequential roles of Hedgehog and Wnt signaling in osteoblast development.Development 132, no. 1 (January 2005): 49–60. https://doi.org/10.1242/dev.01564.
Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005 Jan;132(1):49–60.
Hu, Hongliang, et al. “Sequential roles of Hedgehog and Wnt signaling in osteoblast development.Development, vol. 132, no. 1, Jan. 2005, pp. 49–60. Pubmed, doi:10.1242/dev.01564.
Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005 Jan;132(1):49–60.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

January 2005

Volume

132

Issue

1

Start / End Page

49 / 60

Location

England

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Trans-Activators
  • Time Factors
  • Signal Transduction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Retroviridae
  • Receptors, LDL
  • Proto-Oncogene Proteins
  • Osteoblasts