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Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction.

Publication ,  Journal Article
Bello, NA; Claggett, B; Desai, AS; McMurray, JJV; Granger, CB; Yusuf, S; Swedberg, K; Pfeffer, MA; Solomon, SD
Published in: Circ Heart Fail
July 2014

BACKGROUND: Hospitalization for acute heart failure (HF) is associated with high rates of subsequent mortality and readmission. We assessed the influence of the time interval between previous HF hospitalization and randomization in the Candesartan in Heart failure: Reduction in Mortality and morbidity (CHARM) trials on clinical outcomes in patients with both reduced and preserved ejection fraction. METHODS AND RESULTS: CHARM enrolled 7599 patients with New York Heart Association class II to IV HF, of whom 5426 had a history of previous HF hospitalization. Cox proportional hazards regression models were used to assess the association between time from previous HF hospitalization and randomization and the primary outcome of cardiovascular death or unplanned admission to hospital for the management of worsening HF during a median of 36.6 months. For patients with HF and reduced or preserved ejection fraction, rates of cardiovascular mortality and HF hospitalization were higher among patients with previous HF hospitalization than those without. The risk for mortality and hospitalization varied inversely with the time interval between hospitalization and randomization. Rates were higher for patients with HF and reduced ejection fraction within each category. Event rates for those with HF with preserved ejection fraction and a HF hospitalization in the 6 months before randomization were comparable with the rate in patients with HF and reduced ejection fraction with no previous HF hospitalization. CONCLUSIONS: Rates of cardiovascular death or HF hospitalization are greatest in those who have been previously hospitalized for HF. Independent of EF, rates of death and readmission decline as time from HF hospitalization to trial enrollment increased. Recent HF hospitalization identifies a high-risk population for future clinical trials in HF and reduced ejection fraction and HF with preserved ejection fraction. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00634400.

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Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

July 2014

Volume

7

Issue

4

Start / End Page

590 / 595

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • United States
  • Time Factors
  • Tetrazoles
  • Survival Rate
  • Stroke Volume
  • Retrospective Studies
  • Prognosis
  • Outcome Assessment, Health Care
  • Male
 

Citation

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Bello, N. A., Claggett, B., Desai, A. S., McMurray, J. J. V., Granger, C. B., Yusuf, S., … Solomon, S. D. (2014). Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction. Circ Heart Fail, 7(4), 590–595. https://doi.org/10.1161/CIRCHEARTFAILURE.113.001281
Bello, Natalie A., Brian Claggett, Akshay S. Desai, John J. V. McMurray, Christopher B. Granger, Salim Yusuf, Karl Swedberg, Marc A. Pfeffer, and Scott D. Solomon. “Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction.Circ Heart Fail 7, no. 4 (July 2014): 590–95. https://doi.org/10.1161/CIRCHEARTFAILURE.113.001281.
Bello NA, Claggett B, Desai AS, McMurray JJV, Granger CB, Yusuf S, et al. Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction. Circ Heart Fail. 2014 Jul;7(4):590–5.
Bello, Natalie A., et al. “Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction.Circ Heart Fail, vol. 7, no. 4, July 2014, pp. 590–95. Pubmed, doi:10.1161/CIRCHEARTFAILURE.113.001281.
Bello NA, Claggett B, Desai AS, McMurray JJV, Granger CB, Yusuf S, Swedberg K, Pfeffer MA, Solomon SD. Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction. Circ Heart Fail. 2014 Jul;7(4):590–595.

Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

July 2014

Volume

7

Issue

4

Start / End Page

590 / 595

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • United States
  • Time Factors
  • Tetrazoles
  • Survival Rate
  • Stroke Volume
  • Retrospective Studies
  • Prognosis
  • Outcome Assessment, Health Care
  • Male