Transitioning to and from the novel oral anticoagulants: A management strategy for clinicians

Journal Article

Vitamin K antagonists have been the only available oral anticoagulant therapy for decades until the recent introduction of novel (new) oral anticoagulants. This breakthrough provides patients with alternative treatment choices that have predictable pharmacokinetics and do not require routine coagulation monitoring. Though more convenient from patient perspective, these drugs have distinct pharmacological properties that are particularly important to recognize when transitioning anticoagulant therapies. The following review focuses on transitioning to and from the novel oral anticoagulants, employing a practical pharmacokinetic- and pharmacodynamic-based approach. © 2014 Springer Science+Business Media.

Full Text

Duke Authors

Cited Authors

  • Abo-Salem, E; Becker, R

Published Date

  • 2014

Published In

Volume / Issue

  • 37 / 3

Start / End Page

  • 372 - 379

International Standard Serial Number (ISSN)

  • 0929-5305

Digital Object Identifier (DOI)

  • 10.1007/s11239-014-1060-y