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Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.

Publication ,  Journal Article
Yeo, TW; Lampah, DA; Kenangalem, E; Tjitra, E; Weinberg, JB; Granger, DL; Price, RN; Anstey, NM
Published in: J Infect Dis
November 15, 2014

Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

November 15, 2014

Volume

210

Issue

10

Start / End Page

1627 / 1632

Location

United States

Related Subject Headings

  • Spectroscopy, Near-Infrared
  • Oxygen Consumption
  • Nitric Oxide
  • Microvessels
  • Microbiology
  • Male
  • Malaria, Falciparum
  • Humans
  • Female
  • Endothelial Cells
 

Citation

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Yeo, T. W., Lampah, D. A., Kenangalem, E., Tjitra, E., Weinberg, J. B., Granger, D. L., … Anstey, N. M. (2014). Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria. J Infect Dis, 210(10), 1627–1632. https://doi.org/10.1093/infdis/jiu308
Yeo, Tsin W., Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, J Brice Weinberg, Donald L. Granger, Ric N. Price, and Nicholas M. Anstey. “Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.J Infect Dis 210, no. 10 (November 15, 2014): 1627–32. https://doi.org/10.1093/infdis/jiu308.
Yeo TW, Lampah DA, Kenangalem E, Tjitra E, Weinberg JB, Granger DL, et al. Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria. J Infect Dis. 2014 Nov 15;210(10):1627–32.
Yeo, Tsin W., et al. “Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.J Infect Dis, vol. 210, no. 10, Nov. 2014, pp. 1627–32. Pubmed, doi:10.1093/infdis/jiu308.
Yeo TW, Lampah DA, Kenangalem E, Tjitra E, Weinberg JB, Granger DL, Price RN, Anstey NM. Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria. J Infect Dis. 2014 Nov 15;210(10):1627–1632.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

November 15, 2014

Volume

210

Issue

10

Start / End Page

1627 / 1632

Location

United States

Related Subject Headings

  • Spectroscopy, Near-Infrared
  • Oxygen Consumption
  • Nitric Oxide
  • Microvessels
  • Microbiology
  • Male
  • Malaria, Falciparum
  • Humans
  • Female
  • Endothelial Cells