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Post-transcriptional RNA regulons affecting cell cycle and proliferation.

Publication ,  Journal Article
Blackinton, JG; Keene, JD
Published in: Semin Cell Dev Biol
October 2014

The cellular growth cycle is initiated and maintained by punctual, yet agile, regulatory events involving modifications of cell cycle proteins as well as coordinated gene expression to support cyclic checkpoint decisions. Recent evidence indicates that post-transcriptional partitioning of messenger RNA subsets by RNA-binding proteins help physically localize, temporally coordinate, and efficiently translate cell cycle proteins. This dynamic organization of mRNAs encoding cell cycle components contributes to the overall economy of the cell cycle consistent with the post-transcriptional RNA regulon model of gene expression. This review examines several recent studies demonstrating the coordination of mRNA subsets encoding cell cycle proteins during nuclear export and subsequent coupling to protein synthesis, and discusses evidence for mRNA coordination of p53 targets and the DNA damage response pathway. We consider how these observations may connect to upstream and downstream post-transcriptional coordination and coupling of splicing, export, localization, and translation. Published examples from yeast, nematode, insect, and mammalian systems are discussed, and we consider genetic evidence supporting the conclusion that dysregulation of RNA regulons may promote pathogenic states of growth such as carcinogenesis.

Duke Scholars

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Published In

Semin Cell Dev Biol

DOI

EISSN

1096-3634

Publication Date

October 2014

Volume

34

Start / End Page

44 / 54

Location

England

Related Subject Headings

  • Regulon
  • RNA, Messenger
  • RNA Transport
  • RNA Interference
  • Humans
  • Gene Expression
  • Developmental Biology
  • DNA Damage
  • Cell Proliferation
  • Cell Cycle
 

Citation

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Blackinton, J. G., & Keene, J. D. (2014). Post-transcriptional RNA regulons affecting cell cycle and proliferation. Semin Cell Dev Biol, 34, 44–54. https://doi.org/10.1016/j.semcdb.2014.05.014
Blackinton, Jeff G., and Jack D. Keene. “Post-transcriptional RNA regulons affecting cell cycle and proliferation.Semin Cell Dev Biol 34 (October 2014): 44–54. https://doi.org/10.1016/j.semcdb.2014.05.014.
Blackinton JG, Keene JD. Post-transcriptional RNA regulons affecting cell cycle and proliferation. Semin Cell Dev Biol. 2014 Oct;34:44–54.
Blackinton, Jeff G., and Jack D. Keene. “Post-transcriptional RNA regulons affecting cell cycle and proliferation.Semin Cell Dev Biol, vol. 34, Oct. 2014, pp. 44–54. Pubmed, doi:10.1016/j.semcdb.2014.05.014.
Blackinton JG, Keene JD. Post-transcriptional RNA regulons affecting cell cycle and proliferation. Semin Cell Dev Biol. 2014 Oct;34:44–54.
Journal cover image

Published In

Semin Cell Dev Biol

DOI

EISSN

1096-3634

Publication Date

October 2014

Volume

34

Start / End Page

44 / 54

Location

England

Related Subject Headings

  • Regulon
  • RNA, Messenger
  • RNA Transport
  • RNA Interference
  • Humans
  • Gene Expression
  • Developmental Biology
  • DNA Damage
  • Cell Proliferation
  • Cell Cycle