Efficient purging of deleterious mutations in plants with haploid selfing.

Journal Article

In diploid organisms, selfing reduces the efficiency of selection in removing deleterious mutations from a population. This need not be the case for all organisms. Some plants, for example, undergo an extreme form of selfing known as intragametophytic selfing, which immediately exposes all recessive deleterious mutations in a parental genome to selective purging. Here, we ask how effectively deleterious mutations are removed from such plants. Specifically, we study the extent to which deleterious mutations accumulate in a predominantly selfing and a predominantly outcrossing pair of moss species, using genome-wide transcriptome data. We find that the selfing species purge significantly more nonsynonymous mutations, as well as a greater proportion of radical amino acid changes which alter physicochemical properties of amino acids. Moreover, their purging of deleterious mutation is especially strong in conserved regions of protein-coding genes. Our observations show that selfing need not impede but can even accelerate the removal of deleterious mutations, and do so on a genome-wide scale.

Full Text

Duke Authors

Cited Authors

  • Szövényi, P; Devos, N; Weston, DJ; Yang, X; Hock, Z; Shaw, JA; Shimizu, KK; McDaniel, SF; Wagner, A

Published Date

  • May 14, 2014

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 1238 - 1252

PubMed ID

  • 24879432

Electronic International Standard Serial Number (EISSN)

  • 1759-6653

International Standard Serial Number (ISSN)

  • 1759-6653

Digital Object Identifier (DOI)

  • 10.1093/gbe/evu099

Language

  • eng