Predicting non-coding RNA transcripts

Book Section

Non-coding RNAs are defined as all functional RNA transcripts other than protein encoding messenger RNAs (mRNA). Thus, they are defined more by what they are not than by what they actually are (Fig. 4.1). This unusual way of defining ncRNAs reflects a historical bias in biology. Early biological studies focused largely on prokaryotes, whose genomes are dominated by protein-coding sequence (80-95%) (Mattick 2004a; Mattick and Makunin 2006). This led to the presumption that cellular activities were carried out primarily by proteins. RNA was thought to be a passive carrier of genetic information as mRNA or as supporting molecules for the production of proteins such as transfer-RNA (tRNA) and ribosomal-RNA (rRNA). © Springer Science+Business Media, LLC 2009. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Kavanaugh, LA; Ohler, U

Published Date

  • December 1, 2007

Book Title

  • Bioinformatics: Tools and Applications

Start / End Page

  • 65 - 97

International Standard Book Number 13 (ISBN-13)

  • 9783540241669

Digital Object Identifier (DOI)

  • 10.1007/978-0-387-92738-1_4

Citation Source

  • Scopus