Management of positive sub-areolar/nipple duct margins in nipple-sparing mastectomies.


Journal Article

We evaluated management of positive sub-areolar/nipple duct margins in nipple-sparing mastectomies (NSM) at our institution. Retrospective chart review of all NSM from January 2007 to April 2012 was performed and patient, tumor, and treatment information was collected. Sub-areolar/nipple duct margins included ductal tissue from within the nipple. Of 438 NSM, 22 (5%) had positive sub-areolar/nipple duct margins; 21 of 220 cancer-bearing breasts (10%) and 1 of 218 prophylactic mastectomies (0.5%). Positive margins included four with invasive lobular carcinoma and 18 with ductal carcinoma in situ (DCIS). Management included removal of eight nipples and nine nipple areola complexes (NAC). Four of 17 nipple/NAC specimens had evidence of residual DCIS and none had residual invasive cancer. The majority of nipple/NAC specimens excised for a positive margin had no residual malignancy. Future studies are needed to determine the extent of NAC tissue removal required for positive margins.

Full Text

Duke Authors

Cited Authors

  • Camp, MS; Coopey, SB; Tang, R; Colwell, A; Specht, M; Greenup, RA; Gadd, MA; Brachtel, E; Austen, WG; Smith, BL

Published Date

  • July 2014

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 402 - 407

PubMed ID

  • 24890641

Pubmed Central ID

  • 24890641

Electronic International Standard Serial Number (EISSN)

  • 1524-4741

Digital Object Identifier (DOI)

  • 10.1111/tbj.12279


  • eng

Conference Location

  • United States